99m锝标记人免疫球蛋白闪烁扫描术——检测类风湿关节炎关节活动的可靠方法。
99mTc human immunoglobulin scintigraphy--a reliable method to detect joint activity in rheumatoid arthritis.
作者信息
de Bois M H, Arndt J W, van der Velde E A, van der Lubbe P A, Westedt M L, Pauwels E K, Breedveld F C
机构信息
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
出版信息
J Rheumatol. 1992 Sep;19(9):1371-6.
The ability of 99mtechnetium labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in 30 patients with rheumatoid arthritis (RA). All patients were injected with 350 MBq 99mTc-IgG and imaging was performed 4 h later. This resulted in excellent images of inflamed synovium. Scores for 99mTc-IgG joint scintigraphy correlated highly with scores for joint swelling and C-reactive protein levels, weakly with pain scores and not with radiographic scores of joint destruction. These results suggest that 99mTc-IgG joint scintigraphy may provide an objective test to detect synovitis and measure the activity of the disease.
对30例类风湿性关节炎（RA）患者进行了研究，以探讨99m锝标记的非特异性多克隆人免疫球蛋白G（99mTc-IgG）闪烁扫描术描绘和量化滑膜炎症的能力。所有患者均注射350MBq的99mTc-IgG，并于4小时后进行成像。这产生了炎症滑膜的优质图像。99mTc-IgG关节闪烁扫描的评分与关节肿胀评分和C反应蛋白水平高度相关，与疼痛评分弱相关，与关节破坏的放射学评分无关。这些结果表明，99mTc-IgG关节闪烁扫描术可能提供一种检测滑膜炎和测量疾病活动度的客观测试方法。
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