使用99m锝标记的非特异性人免疫球蛋白评估类风湿关节炎和其他关节炎的疾病活动度。
Evaluation of disease activity in rheumatoid arthritis and other arthritides using 99mtechnetium labeled nonspecific human immunoglobulin.
作者信息
Jamar F, Manicourt D H, Leners N, Vanden Berghe M, Beckers C
机构信息
Center of Nuclear Medicine, University of Louvain Medical School, Brussels, Belgium.
出版信息
J Rheumatol. 1995 May;22(5):850-4.
OBJECTIVE
To determine the usefulness of 99mtechnetium (99mTc) immunoglobulin scintigraphy (99mTc IgG) in rheumatoid arthritis (RA) and in other arthritides.
METHODS
Scintigraphic scores were compared with the Ritchie index and biochemical variables of disease activity.
RESULTS
In RA, scintigraphic scores were reproducible and seemed to perform better than clinical scores. Moreover, the scores of synovial uptake correlated significantly with systemic variables of inflammation. Other inflammatory arthritides also disclosed uptake of 99mTc IgG but noninflammatory joints did not.
CONCLUSION
Although nonspecific for RA, 99mTc IgG scintigraphy is a reliable tool to evaluate the degree and extent of joint inflammation.
目的
确定锝-99m（99mTc）免疫球蛋白闪烁扫描术（99mTc IgG）在类风湿关节炎（RA）及其他关节炎中的应用价值。
方法
将闪烁扫描评分与里奇指数及疾病活动的生化指标进行比较。
结果
在类风湿关节炎中，闪烁扫描评分具有可重复性，且似乎比临床评分表现更好。此外，滑膜摄取评分与全身炎症指标显著相关。其他炎性关节炎也显示有99mTc IgG摄取，但非炎性关节则没有。
结论
尽管99mTc IgG闪烁扫描术对类风湿关节炎不具有特异性，但它是评估关节炎症程度和范围的可靠工具。
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