de Bois M H, Tak P P, Arndt J W, Kluin P M, Pauwels E K, Breedveld F C
Department of Rheumatology, University Hospital Leiden, The Netherlands.
Clin Exp Rheumatol. 1995 Mar-Apr;13(2):155-9.
This study addressed the following questions: How does 99mTc-IgG scintigraphy compare to physical examination in the detection of synovitis as determined histologically, and is 99mTc-IgG scintigraphy a sensitive detector of histologically documented synovitis activity in the absence of clinically detectable knee joint swelling?
The results of measuring synovitis activity by physical examination and by scintigraphy with technetium-99m labelled polyclonal human immunoglobulin G (99mTc-IgG) were compared with the results of histological examination of synovial biopsies taken from the knee joints of patients with rheumatoid arthritis (n = 21), osteoarthritis (n = 9) and various other rheumatic diseases (n = 10).
The sensitivity of 99mTc-IgG scintigraphy in detecting synovitis activity, as determined histologically (85%), was higher than the sensitivity of joint swelling (65%). In the absence of clinically detectable knee joint swelling the sensitivity of 99mTc-IgG scintigraphy was 83%.
This study shows that 99mTc-IgG scintigraphy is a more sensitive method than physical examination in detecting histologically documented synovitis activity.
本研究探讨了以下问题：在通过组织学确定滑膜炎的检测中，99mTc-IgG闪烁扫描与体格检查相比如何？在没有临床可检测到的膝关节肿胀的情况下，99mTc-IgG闪烁扫描是否是组织学记录的滑膜炎活动的敏感检测方法？
将通过体格检查和用99m锝标记的多克隆人免疫球蛋白G（99mTc-IgG）闪烁扫描测量滑膜炎活动的结果，与对类风湿性关节炎患者（n = 21）、骨关节炎患者（n = 9）和各种其他风湿性疾病患者（n = 10）膝关节滑膜活检的组织学检查结果进行比较。
99mTc-IgG闪烁扫描检测组织学确定的滑膜炎活动的敏感性（85%）高于关节肿胀的敏感性（65%）。在没有临床可检测到的膝关节肿胀的情况下，99mTc-IgG闪烁扫描的敏感性为83%。
本研究表明，在检测组织学记录的滑膜炎活动方面，99mTc-IgG闪烁扫描是比体格检查更敏感的方法。
