Watanabe W, Baker D G, Schumacher H R
University of Pennsylvania School of Medicine, Philadelphia.
J Rheumatol. 1992 Sep;19(9):1453-7.
Pure monoclinic or triclinic calcium pyrophosphate dihydrate (CPPD) crystals, apatite crystals or mixtures of these crystals were injected into the synovial-like space created by the rat air pouch to compare the acute inflammation induced by these crystals. Fluids were withdrawn 6 h after injection and examined for leukocyte counts, protease, prostaglandin E2 (PGE2) and tumor necrosis factor (TNF) levels. CPPD crystals (especially monoclinic CPPD) induced higher numbers of leukocytes, and more protease, PGE2 and TNF than apatite. CPPD seemed to play a predominant role in the acute inflammation induced by mixed crystals.
将纯单斜晶系或三斜晶系的二水焦磷酸钙（CPPD）晶体、磷灰石晶体或这些晶体的混合物注入大鼠气囊肿形成的类似滑膜的腔隙中，以比较这些晶体诱导的急性炎症。注射后6小时抽取液体，检测白细胞计数、蛋白酶、前列腺素E2（PGE2）和肿瘤坏死因子（TNF）水平。与磷灰石相比，CPPD晶体（尤其是单斜晶系CPPD）诱导的白细胞数量更多，蛋白酶、PGE2和TNF也更多。在混合晶体诱导的急性炎症中，CPPD似乎起主要作用。
