Synthesis and biological activity of 13-epi-avermectins: potent anthelmintic agents with an increased margin of safety.
作者信息
Blizzard T A, Margiatto G M, Mrozik H, Shoop W L, Frankshun R A, Fisher M H
机构信息
Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.
出版信息
J Med Chem. 1992 Oct 16;35(21):3873-8. doi: 10.1021/jm00099a014.
PMID:1433196
Abstract
Chemical conversion of the potent anthelmintic natural products avermectin B1 (1) and avermectin B2 (3) to the corresponding 13-epi analogs (15 and 9) is described. The novel analogs retain the full potency of the natural products but are substantially safer.
摘要
Zotero 插件