Pan Jun-jie, Wan Xu, Zhang Hui, Chen Zhen, Huang Jun, Yang Bo, Chen An-liang, Wang Ji-dong
Provincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University, Lin'An, China.
Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, China.
J Antibiot (Tokyo). 2016 Feb;69(2):104-7. doi: 10.1038/ja.2015.90. Epub 2015 Sep 2.
Three new β-class milbemycins, 13α-hydroxy-4-ethy1 milbemycin β3 (1), 13α-hydroxy-25-ethy1 milbemycin β3 (2), 13α-hydroxy milbemycin β3 (3), were isolated from the broth of the genetically engineered strains Streptomyces avermitilis MHJ1011, whose aveA1 gene was replaced by milA1 gene seamlessly. Their structures were determined on the basis of extensive spectroscopic analysis and comparison with data from the literature. These three compounds, especially compound 1, exhibited potent acaricidal activity.
从基因工程菌株阿维链霉菌MHJ1011的发酵液中分离出三种新的β-类米尔倍霉素，即13α-羟基-4-乙基米尔倍霉素β3（1）、13α-羟基-25-乙基米尔倍霉素β3（2）、13α-羟基米尔倍霉素β3（3），该菌株的aveA1基因已被milA1基因无缝替换。通过广泛的光谱分析并与文献数据进行比较确定了它们的结构。这三种化合物，尤其是化合物1，表现出强效杀螨活性。
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