氧-血红蛋白系统：一种促进膜转运的模型。

OXYGEN-HEMOGLOBIN SYSTEM: A MODEL FOR FACILITATED MEMBRANOUS TRANSPORT.

作者信息

ZILVERSMIT D B

出版信息

Science. 1965 Aug 20;149(3686):874-6. doi: 10.1126/science.149.3686.874.

DOI:10.1126/science.149.3686.874

Abstract

Enhanced transport of oxygen in a Millipore filter containing a solution of hemoglobin can be accounted for by the diffusion of free oxygen as well as of hemoglobin-bound oxygen. A model shows that, at oxygen tensions at which the hemoglobin is fully saturated in a portion of the membrane, the enhanced transport is due to a steeper gradient for free oxygen, whereas in the rest of the membrane an "(oxy)hemoglobin shuttle" operates. A similar model may be useful for explaining facilitated diffusion in other systems.

摘要

在含有血红蛋白溶液的微孔滤膜中，氧气传输的增强可归因于游离氧以及与血红蛋白结合的氧的扩散。一个模型表明，在膜的一部分中血红蛋白完全饱和的氧分压下，传输增强是由于游离氧的梯度更陡，而在膜的其余部分，一个“（氧合）血红蛋白穿梭”机制在起作用。类似的模型可能有助于解释其他系统中的易化扩散。