Tallarigo C, Baldassarre R, Bianchi G, Comunale L, Olivo G, Pea M, Bonetti F, Martignoni G, Zamboni G, Mobilio G
Cattedra e Divisione Clinicizzata di Urologia, Ospedale Policlinico, Università degli Studi di Verona, Italy.
J Urol. 1992 Dec;148(6):1880-4. doi: 10.1016/s0022-5347(17)37057-x.
Multicentric renal angiomyolipoma is a rare form of benign tumor. However, its effective incidence as evaluated in autopsy studies may be as high as 8%. There are 2 main types of renal angiomyolipoma, that is isolated forms and those associated with other diseases, such as phakomatosis, polycystic kidneys and fibromuscular dysplasia. The tumor may also display malignant behavior with local invasiveness and regional lymph node involvement. However, the clinical course is benign and multicentricity is important for prognosis. Histopathological diagnosis often is difficult. Immunohistochemical analysis of surgical specimens using a panel of monoclonal antibodies, including HMB-45 and actin, enabled us to make a definitive diagnosis in 3 cases of multicentric renal angiomyolipoma.
多中心性肾血管平滑肌脂肪瘤是一种罕见的良性肿瘤形式。然而，根据尸检研究评估，其实际发病率可能高达8%。肾血管平滑肌脂肪瘤主要有两种类型，即孤立型和与其他疾病相关的类型，如错构瘤病、多囊肾和纤维肌发育不良。该肿瘤也可能表现出恶性行为，伴有局部侵袭和区域淋巴结受累。然而，临床病程是良性的，多中心性对预后很重要。组织病理学诊断往往很困难。使用一组单克隆抗体（包括HMB-45和肌动蛋白）对手术标本进行免疫组织化学分析，使我们能够对3例多中心性肾血管平滑肌脂肪瘤做出明确诊断。
