Hamada H
Department of Anesthesiology, Kawasaki Medical School, Kurashiki.
Masui. 1992 Sep;41(9):1426-33.
Changes of circulating blood volume during isoflurane or sevoflurane anesthesia were investigated by the dual indicator dilution method in eighteen mongrel dogs. The animals were randomly divided into three groups; control (C) group n = 6, isoflurane (I) group n = 6, and sevoflurane (S) group n = 6. The values of circulating blood volume (ml.kg-1) at 0, 0.5 and 1.0 MAC period were 90.1 +/- 18.7----87.5 +/- 17.2----94.1 +/- 23.6 in the I group and 91.6 +/- 12.5----96.5 +/- 15.0----94.1 +/- 8.5 in the S group, respectively. No significant changes were found in both groups concerning circulating blood volume, red cell volume, and plasma volume, but circulating blood volume and plasma volume tended to increase slightly in both groups at 0.5 and 1.0 MAC period compared with 0 MAC period. Mean arterial pressure decreased 68% of the initial value in the I group at the 1.0 and 78% stages in the S group. Cardiac index tended to increase from 2.6 +/- 0.4 l.min-1.m2 to 3.2 +/- 0.9 in the I group at the stage 1.0 but to decrease from 5.2 +/- 1.4 l.min-1.m2 to 4.1 +/- 0.9 in the S group. It was suggested that the increase of venous pressure resulted in the significant decrease of plasma volume. Increase of intrathoracic pressure during positive pressure ventilation might partially influence the blood volume change. Our data suggest that isoflurane and sevoflurane do not greatly affect the circulating blood volume under control ventilation.
采用双指示剂稀释法，在18只杂种犬中研究了异氟烷或七氟烷麻醉期间循环血容量的变化。动物被随机分为三组：对照组（C组）n = 6，异氟烷（I组）n = 6，七氟烷（S组）n = 6。I组在0、0.5和1.0 MAC期的循环血容量（ml.kg-1）值分别为90.1±18.7----87.5±17.2----94.1±23.6，S组分别为91.6±12.5----96.5±15.0----94.1±8.5。两组的循环血容量、红细胞容量和血浆容量均无显著变化，但与0 MAC期相比，两组在0.5和1.0 MAC期的循环血容量和血浆容量均有轻微增加的趋势。I组在1.0 MAC期平均动脉压降至初始值的68%，S组在该阶段降至78%。I组心脏指数在1.0 MAC期从2.6±0.4 l.min-1.m2增至3.2±0.9，而S组则从5.2±1.4 l.min-1.m2降至4.1±0.9。提示静脉压升高导致血浆容量显著减少。正压通气期间胸内压升高可能部分影响血容量变化。我们的数据表明，在控制通气条件下，异氟烷和七氟烷对循环血容量影响不大。
