Kobayashi M
Department of Anesthesiology, Nippon Medical School, Tokyo, Japan.
Masui. 1996 Mar;45(3):281-6.
The influences of sevoflurane and isoflurane on hepatic blood flow (HBF) in man were investigated employing the method of continuous infusion of indocyanine green. HBF and cardiac output (CO) were measured in patients before and after induction of anesthesia with thiamylal, fentanyl, and N2O, and again during isoflurane (n = 9) or sevoflurane (n = 8) anesthesia before the start of surgery. HBF after administration of volate anesthetics increased significantly with 1MAC isoflurane, and decreased with 1 MAC sevoflurane. Although CO decreased similarly in both groups during anesthesia, the HBF/CO ratio in isoflurane group increased significantly, and the ratio in sevoflurane group did not change significantly. We conclude that whereas isoflurane increases HBF, sevoflurane does not change it in anesthetized patients.
采用持续输注吲哚菁绿的方法，研究了七氟醚和异氟醚对人体肝血流量（HBF）的影响。在硫喷妥钠、芬太尼和N2O诱导麻醉前后，以及在手术开始前异氟醚（n = 9）或七氟醚（n = 8）麻醉期间，测量患者的肝血流量和心输出量（CO）。给予挥发性麻醉剂后，1MAC异氟醚使肝血流量显著增加，而1MAC七氟醚使其降低。虽然两组在麻醉期间心输出量均同样降低，但异氟醚组的肝血流量/心输出量比值显著增加，七氟醚组的该比值无显著变化。我们得出结论，在麻醉患者中，异氟醚可增加肝血流量，而七氟醚则不会改变肝血流量。
