Sonoda Y
Department of Hygiene, Kyoto Prefectural University of Medicine.
Nihon Rinsho. 1992 Aug;50(8):1821-6.
Interleukin-9 (IL-9)/P40 is a recently reported murine growth factor for helper T-cell clones. It is produced by ConA stimulated CD4+ T-cells or several T-cell lines such as TUC 2.15 derived from C57Bl/6 mouse. In the murine system, IL-9/P40 directly supported proliferation of mucosal type mast cells, and also induced erythroid burst formation, indirectly. On the other hand, human IL-9, which is a homologue to murine P40, was cloned from a cDNA library prepared with mRNA isolated from PHA-induced T-cell line (C5MJ2). Analysis of the sequence of cDNA revealed a striking similarity between murine and human IL-9/P40. Human IL-9 supported formation of a subpopulation of erythroid bursts that are responsive to IL-3. In this communication, identification, cloning of cDNA, and biological activities of murine and human IL-9/P40 are discussed.
白细胞介素-9（IL-9）/P40是最近报道的一种辅助性T细胞克隆的小鼠生长因子。它由刀豆蛋白A刺激的CD4+ T细胞或几种T细胞系产生，如源自C57Bl/6小鼠的TUC 2.15。在小鼠系统中，IL-9/P40直接支持黏膜型肥大细胞的增殖，也间接诱导红系爆式集落形成。另一方面，人IL-9是小鼠P40的同源物，它是从用从PHA诱导的T细胞系（C5MJ2）分离的mRNA制备的cDNA文库中克隆出来的。对cDNA序列的分析揭示了小鼠和人IL-9/P40之间的显著相似性。人IL-9支持对IL-3有反应的红系爆式集落亚群的形成。在本通讯中，讨论了小鼠和人IL-9/P40的鉴定、cDNA克隆及生物学活性。
