Nakahata T, Tsuji K
Department of Pediatrics, Shinshu University School of Medicine.
Nihon Rinsho. 1992 Aug;50(8):1827-32.
Interleukin-10 has a variety of biological activities. Murine interleukin-10 inhibits cytokine production by Th2 cells in the presence of macrophages, enhances T cell proliferation, sustains the viability of B cells in vitro, induces class II MHC antigen expression on B cells, enhances mast cell proliferation in the presence of IL-3 and/or IL-4, and inhibits cytokine production by macrophages. Human interleukin-10 inhibits cytokine production by human T cells and reduces antigen-specific human T cell proliferation by downregulation of class II MHC antigen expression on monocytes. cDNA clones encoding murine and human interleukin-10 exhibit a strong homology to BCRFI in Epstein-Barr virus. BCRFI conserves only a part of interleukin-10 activities.
白细胞介素-10具有多种生物学活性。小鼠白细胞介素-10在巨噬细胞存在的情况下抑制Th2细胞产生细胞因子，增强T细胞增殖，在体外维持B细胞的活力，诱导B细胞上II类MHC抗原表达，在IL-3和/或IL-4存在的情况下增强肥大细胞增殖，并抑制巨噬细胞产生细胞因子。人白细胞介素-10抑制人T细胞产生细胞因子，并通过下调单核细胞上II类MHC抗原表达来减少抗原特异性人T细胞增殖。编码小鼠和人白细胞介素-10的cDNA克隆与爱泼斯坦-巴尔病毒中的BCRFI具有很强的同源性。BCRFI仅保留了白细胞介素-10的部分活性。
