白细胞介素-10基因多态性和单倍型在多囊卵巢综合征风险中的作用。
Role of interleukin-10 polymorphisms and haplotypes in polycystic ovary syndrome risk.
作者信息
Xing Guanlin, Sun Yingpu, Wang Fang, Gao Guozheng, Zhou Xiaojing
机构信息
Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China.
Department of Reproductive Medicine, Luoyang Center Hospital Affiliated to Zhengzhou University Luoyang, China.
出版信息
Int J Clin Exp Pathol. 2017 Jul 1;10(7):7956-7961. eCollection 2017.
Polycystic ovary syndrome (PCOS) is one of the most frequently encountered endocrine malfunctions. The etiology of PCOS is complex and unclear. We aimed to investigate the role of three common SNPs (rs1800896, rs1800871 and rs1800872) of IL-10 in the development of PCOS in a Chinese population. We recruited 360 patients with PCOS and 360 healthy controls in this study. SNP genotyping of IL-10 rs1800896, rs1800871 and rs1800872 was implemented in a 384-well plate format on the Sequenom MassARRAY System (Sequenom, San Diego, USA). Individuals carrying the GG genotype of rs1800872 were associated with an increased risk of PCOS when compared with the AA genotype (OR = 3.04, 95% CI = 1.62-5.69). No linkage disequilibrium was observed among IL-10 rs1800896, rs1800871 and rs1800872. The C-T-A (OR = 1.53, 95% CI = 1.05-2.35) haplotype indicated an increased risk of PCOS, while the A-C-G (OR = 0.72, 95% CI = 0.53-0.98) showed a reduced risk of PCOS. In summary, this study firstly estimates the association between IL-10 polymorphisms and haplotype and PCOS risk in the Chinese population.
多囊卵巢综合征（PCOS）是最常见的内分泌功能紊乱之一。PCOS的病因复杂且不明。我们旨在研究白细胞介素-10（IL-10）的三个常见单核苷酸多态性（rs1800896、rs1800871和rs1800872）在中国人群PCOS发病中的作用。本研究招募了360例PCOS患者和360例健康对照。在Sequenom MassARRAY系统（美国圣地亚哥的Sequenom公司）上以384孔板形式对IL-10的rs1800896、rs1800871和rs1800872进行单核苷酸多态性基因分型。与AA基因型相比，携带rs1800872的GG基因型个体患PCOS的风险增加（比值比[OR]=3.04，95%置信区间[CI]=1.62-5.69）。未观察到IL-10的rs1800896、rs1800871和rs1800872之间存在连锁不平衡。C-T-A单倍型（OR=1.53，95%CI=1.05-2.35）表明患PCOS的风险增加，而A-C-G单倍型（OR=0.72，95%CI=0.53-0.98）显示患PCOS的风险降低。总之，本研究首次评估了中国人群中IL-10基因多态性和单倍型与PCOS风险之间的关联。
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