Bygdeman M, Swahn M L
Law Med Health Care. 1992 Fall;20(3):157-60. doi: 10.1111/j.1748-720x.1992.tb01183.x.
The Swedish experience indicates that the combination of RU 486 and vaginal or intramuscular administration of different prostaglandin analogues such as Cervagem, Sulprostone, and 15- methyl PGF2 alpha is a highly effective and safe non-surgical method to terminate early pregnancy. The combined treatment may also be used during the second trimester. In mid- and late second trimester abortion this procedure represents a simple, non-invasive, highly effective method. There are several possibilities by which RU 486 can be used as a contraceptive. We have shown that post-ovulatory administration of RU 486 will effectively inhibit implantation. If the preliminary results are confirmed, treatment with RU 486 once a month on day LH+2 may be an attractive alternative to present contraceptive technology.
瑞典的经验表明，将RU 486与不同前列腺素类似物（如卡孕栓、硫前列酮和15-甲基前列腺素F2α）经阴道或肌肉注射联合使用，是一种终止早期妊娠的高效且安全的非手术方法。这种联合治疗也可用于妊娠中期。在妊娠中期和晚期流产时，该方法是一种简单、无创且高效的方法。RU 486有几种用作避孕药的可能性。我们已经表明，排卵后给予RU 486可有效抑制着床。如果初步结果得到证实，在促黄体生成素（LH）+2日每月使用一次RU 486进行治疗，可能是现有避孕技术的一种有吸引力的替代方法。
