Avrech O M, Golan A, Weinraub Z, Bukovsky I, Caspi E
Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel.
Fertil Steril. 1991 Sep;56(3):385-93. doi: 10.1016/s0015-0282(16)54527-0.
The availability of a medical mode of termination of early pregnancy by the administration of RU486, an antiprogesterone alone, or in combination with one of the PG analogues significantly reduces the maternal morbidity and mortality associated with the classical surgical abortion. RU486 given alone in early pregnancy induces complete abortion in 60% to 85% of cases, and when combined with prostaglandin analogues, gemeprost or sulprostone, reaches a success rate of 95% to 99%. RU486 may also be of potential value in the medical treatment of ectopic pregnancy. Its use as a postcoital contraception is suggested, but further research is required to determine whether RU486 can be used on a once-a-month basis for contraception.
通过单独使用抗孕激素RU486或与一种前列腺素类似物联合使用来实现早期妊娠终止的医学模式，显著降低了与传统手术流产相关的孕产妇发病率和死亡率。在妊娠早期单独使用RU486可使60%至85%的病例完全流产，与前列腺素类似物米索前列醇或硫前列酮联合使用时，成功率可达95%至99%。RU486在异位妊娠的医学治疗中可能也具有潜在价值。有人建议将其用作性交后避孕，但还需要进一步研究以确定RU486是否可每月使用一次用于避孕。
