Paterson D L, King M A, Boyle R S, Pond S M, Whitby M, Wright M, Henderson A
Princess Alexandra Hospital, Woolloongabba, Qld.
Med J Aust. 1992 Aug 17;157(4):269-70. doi: 10.5694/j.1326-5377.1992.tb137135.x.
To present a case of adult botulism acquired in Queensland.
After eating home-preserved asparagus, a 33-year-old man presented with internal and external ophthalmoplegia, bilateral facial nerve palsies, and descending muscle weakness culminating in a sudden respiratory arrest. Electrophysiological testing demonstrated normal nerve conduction velocities and an incremental response of evoked motor potentials on repetitive stimulation, confirming the clinical diagnosis of botulism.
Treatment with trivalent antitoxin, oral treatment with vancomycin and supportive mechanical ventilation for four weeks resulted in complete clinical recovery. Plasmapheresis was also used but its contribution to the patient's improvement is dubious.
Although botulism is rare in Australia, clinicians should be aware of the clinical presentation and the rapidity of confirmation of the diagnosis by electrophysiological testing. Patients should be nursed in an intensive care setting. Regular testing of vital capacity should be performed to determine the need for mechanical ventilation.
介绍一例在昆士兰州感染的成人肉毒中毒病例。
一名33岁男子在食用自家腌制的芦笋后,出现眼内肌和眼外肌麻痹、双侧面神经麻痹以及进行性肌肉无力,最终突然呼吸骤停。电生理测试显示神经传导速度正常,重复刺激时诱发运动电位呈递增反应,证实了肉毒中毒的临床诊断。
使用三价抗毒素治疗、口服万古霉素并进行四周的支持性机械通气,患者实现了完全临床康复。也进行了血浆置换,但它对患者病情改善的作用尚不确定。
尽管肉毒中毒在澳大利亚较为罕见,但临床医生应了解其临床表现以及通过电生理测试快速确诊的方法。患者应在重症监护环境中护理。应定期进行肺活量测试以确定是否需要机械通气。