Department of Medicine and Pharmacy, Free University of Brussel, Brussels, Belgium.
Department of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
J Med Case Rep. 2023 Apr 15;17(1):139. doi: 10.1186/s13256-023-03885-2.
Botulism is a rare neuroparalytic disease that has only presented itself 19 times in the last 30 years in Belgium. Patients present to emergency services with a wide range of complaints. Foodborne botulism is a forgotten yet life-threatening disease.
We describe a case of a Caucasian female in her 60s that presented to the emergency with reflux with nausea and spasmodic epigastric pain, no vomiting, dry mouth, and weakness in both legs. The symptoms started after ingestion of Atlantic wolffish. After exclusion of other more common causes, foodborne botulism was suspected. The patient was admitted to the intensive care unit for mechanical ventilation. Following treatment with trivalent botulinum antitoxin, she made a full neurologic recovery.
It is important to rapidly recognize the possible diagnosis of botulism even if the neurological symptoms are not dominant. Rapid neurologic dysfunction and respiratory difficulties starts between 6 and 72 hours after ingestion. The decision to administer antitoxins should, however, be based on the presumptive clinical diagnosis and diagnosis should not delay therapy.
肉毒中毒是一种罕见的神经麻痹性疾病,在过去 30 年中,仅在比利时出现过 19 次。患者因各种症状就诊于急救中心。食源性肉毒中毒是一种被遗忘但危及生命的疾病。
我们描述了一位 60 多岁的白人女性病例,她因反流伴恶心和痉挛性上腹痛、无呕吐、口干和双下肢无力就诊于急救中心。症状在摄入大西洋狼鱼后开始出现。在排除其他更常见的病因后,怀疑为食源性肉毒中毒。患者因机械通气而入住重症监护病房。在使用三价肉毒杆菌抗毒素治疗后,她完全恢复了神经功能。
即使神经症状不占主导地位,也应迅速识别肉毒中毒的可能诊断。在摄入后 6 至 72 小时内,快速出现神经功能障碍和呼吸困难。然而,给予抗毒素的决定应基于推测的临床诊断,并且诊断不应延迟治疗。