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[一例因自制香蒜酱导致的严重神经麻痹性食源性肉毒中毒的单纯支持治疗病例]

[A case of sole supportive care of severe neuroparalytic foodborne botulism due to homemade pesto].

作者信息

Kuratle M, Baldinger R, Lienhardt Nobbe B, Dreessen P, Yuen B

机构信息

Interdisziplinäre Intensivstation, Spital Bülach, 8180, Bülach, Schweiz.

Doktor Zentrum Wettingen, Bahnhofstraße 88, 5430, Wettingen, Schweiz.

出版信息

Med Klin Intensivmed Notfmed. 2019 Feb;114(1):59-62. doi: 10.1007/s00063-018-0430-1. Epub 2018 Apr 11.

DOI:10.1007/s00063-018-0430-1
PMID:29644402
Abstract

In this article, a case of severe foodborne botulism in a 78-year-old man due to homemade pesto is presented. His initial symptoms were gastrointestinal problems. Later he suffered of cranial nerve palsies, muscle weakness of the upper extremities and respiratory failure, so he had to be admitted to the intensive care unit for mechanical ventilation. The botulism was confirmed by serology and culture. Because of spontaneously improving neurological deficits, we decided not to treat with the botulism antitoxin and the patient had complete clinical remission.

摘要

本文介绍了一例78岁男性因自制香蒜酱导致严重食源性肉毒中毒的病例。他最初的症状是胃肠道问题。后来,他出现了颅神经麻痹、上肢肌肉无力和呼吸衰竭,因此不得不入住重症监护病房进行机械通气。通过血清学和培养确诊为肉毒中毒。由于神经功能缺损自发改善,我们决定不使用肉毒抗毒素进行治疗,患者临床完全缓解。

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本文引用的文献

1
Safety and Improved Clinical Outcomes in Patients Treated With New Equine-Derived Heptavalent Botulinum Antitoxin.新型马源七价肉毒毒素抗毒素治疗患者的安全性和临床结局改善。
Clin Infect Dis. 2017 Dec 27;66(suppl_1):S57-S64. doi: 10.1093/cid/cix816.
2
Efficacy of Antitoxin Therapy in Treating Patients With Foodborne Botulism: A Systematic Review and Meta-analysis of Cases, 1923-2016.抗毒素治疗在治疗食源性肉毒中毒患者中的疗效:1923-2016 年病例的系统评价和荟萃分析。
Clin Infect Dis. 2017 Dec 27;66(suppl_1):S43-S56. doi: 10.1093/cid/cix815.
3
Clinical Features of Foodborne and Wound Botulism: A Systematic Review of the Literature, 1932-2015.
食源性和创伤性肉毒中毒的临床特征:1932-2015 年文献的系统评价。
Clin Infect Dis. 2017 Dec 27;66(suppl_1):S11-S16. doi: 10.1093/cid/cix811.
4
[Botulism: Diagnosis and Therapy].[肉毒中毒:诊断与治疗]
Dtsch Med Wochenschr. 2017 Sep;142(17):1304-1312. doi: 10.1055/s-0043-112232. Epub 2017 Aug 29.
5
A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins.一种产生 B 型和 H 型肉毒毒素的新型肉毒梭菌。
J Infect Dis. 2014 Jan 15;209(2):183-91. doi: 10.1093/infdis/jit449. Epub 2013 Oct 7.
6
Botulism: the challenge of diagnosis and treatment.肉毒中毒:诊断与治疗的挑战
Rev Neurol Dis. 2006 Fall;3(4):182-9.