Fuchs J, Pecher S
Zentrum der Dermatologie und Venerologie, Abteilung II, Klinikum der Johann Wolfgang Goethe Universität Frankfurt, Germany.
Mycopathologia. 1992 Aug;119(2):73-6. doi: 10.1007/BF00443936.
The cellular immune response of 8 patients from the Brazilian Amazon region with chromoblastomycosis was analyzed. Primary immunological responses of patients were tested by contact sensitization to 2,4-dinitro-chlorobenzene (DNCB), or rejection of first set skin allografts. 2 of 8 patients were reactive to DNCB after sensitization, and skin allograft rejection occurred in an average of 14 days. Capacity of patients to mount recall immunological responses was measured by skin testing with two fungal antigens and three bacterial antigens. Delayed skin reaction to trichophytin and candida antigens was negative in the majority of the patients. However, reactivity to mycobacterial (tuberculin), and bacterial (staphylococcal, streptococcal) antigen was high, or only slightly diminished respectively. The data suggest that patients with chromoblastomycosis have suppressed nonspecific, cell mediated immunity for some antigens (skin allografts, DNCB, fungal antigens), while reactivity to bacterial and mycobacterial antigens is not impaired.
对来自巴西亚马逊地区的8例着色芽生菌病患者的细胞免疫反应进行了分析。通过对2,4-二硝基氯苯（DNCB）的接触致敏或首次同种异体皮肤移植的排斥反应来测试患者的初次免疫反应。8例患者中有2例在致敏后对DNCB有反应，皮肤同种异体移植排斥反应平均发生在14天。通过用两种真菌抗原和三种细菌抗原进行皮肤试验来测量患者产生回忆免疫反应的能力。大多数患者对毛癣菌素和念珠菌抗原的迟发性皮肤反应为阴性。然而，对分枝杆菌（结核菌素）和细菌（葡萄球菌、链球菌）抗原的反应性分别较高或仅略有降低。数据表明，着色芽生菌病患者对某些抗原（同种异体皮肤移植、DNCB、真菌抗原）的非特异性细胞介导免疫受到抑制，而对细菌和分枝杆菌抗原的反应性未受损。
