进行性核上性麻痹患者大脑中伴有直小管的神经胶质原纤维缠结。
Glial fibrillary tangles with straight tubules in the brains of patients with progressive supranuclear palsy.
作者信息
Nishimura M, Namba Y, Ikeda K, Oda M
机构信息
Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan.
出版信息
Neurosci Lett. 1992 Aug 31;143(1-2):35-8. doi: 10.1016/0304-3940(92)90227-x.
A recent report has described the appearance of silver positive, tau-immunoreactive astrocytes in the brains of patients with progressive supranuclear palsy (PSP) (Neurosci. Lett., 135 (1992) 99-102). In this study we confirmed this finding in two cases of PSP by using Bodian silver staining and immunohistochemistry with antibody to human tau protein. By electron microscopy we demonstrated that fibrillary masses present in these unique astrocytes were made up of straight tubules that were indistinguishable from those of neurofibrillary tangles of PSP. The term 'glial fibrillary tangle' was proposed for these structures.
最近的一份报告描述了进行性核上性麻痹（PSP）患者大脑中出现的银染色阳性、tau蛋白免疫反应性星形胶质细胞（《神经科学快报》，135卷（1992年）99 - 102页）。在本研究中，我们通过使用博迪安银染色法以及针对人tau蛋白的抗体进行免疫组织化学，在两例PSP患者中证实了这一发现。通过电子显微镜，我们证明这些独特星形胶质细胞中存在的纤维状团块是由直的小管组成，这些小管与PSP神经原纤维缠结中的小管无法区分。我们为这些结构提出了“胶质纤维缠结”这一术语。
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