Schmid K O, Mutz I, Ritzinger I
Virchows Arch A Pathol Anat Histol. 1977 Sep 28;375(3):249-56. doi: 10.1007/BF01102993.
Two boys, aged 5 1/4 and 10 1/4, respectively, with acute immature-cell leukosis, died of massive cerebral haemorrhage. Their eyes showed extensive leukaemic involvement of the retina with development of numerous miliary leukaemic nodules; the vitreous of case 2 was also involved. The lesions were considered to have developed because of high circulating white cell counts, a tendency of blast cells to produce nodules, an oxygen poor avascular matrix in which to grow, and a physical environment which permitted growth without haemorrhage or distortion due to tissue pressures etc. Using histological methods, an attempt is made to trace the pattern of formation of the nodule, from an initial growing focus through "colonial" form resembling a bacterial colony to lysis. Necrotic blast cells are apparently a metabolic source for viable tumour cells. Their localization in the eye makes access by cytotoxic drugs difficult; thus they should be considered as blast cell pools.
两名分别为5岁零3个月和10岁零3个月的男孩患有急性未成熟细胞白血病，均死于大面积脑出血。他们的眼睛显示视网膜有广泛的白血病浸润，出现了许多粟粒状白血病结节；病例2的玻璃体也受到了累及。这些病变被认为是由于循环白细胞计数高、原始细胞易于形成结节、存在利于生长的缺氧无血管基质以及有允许生长而不会因组织压力等导致出血或变形的物理环境所致。利用组织学方法，试图追踪结节的形成模式，从最初的生长灶到类似细菌菌落的“菌落”形式再到溶解。坏死的原始细胞显然是存活肿瘤细胞的代谢来源。它们在眼部的定位使得细胞毒性药物难以到达；因此，它们应被视为原始细胞池。
