Onks D L, Robertson A F, Brodersen R
Department of Paediatrics, East Carolina University School of Medicine, Greenville, North Carolina 27858.
Pharmacol Toxicol. 1992 Sep;71(3 Pt 1):196-7. doi: 10.1111/j.1600-0773.1992.tb00544.x.
Chloral hydrate is used as a sedative in infants requiring ventilatory support. The metabolites, trichloroethanol and trichloroacetic acid, accumulate in the serum and are protein bound. The possibility that these chemicals might compete with bilirubin for albumin binding was tested using the peroxidase method and a dialysis rate method. Chloral hydrate and trichloroethanol had no effect on bilirubin-albumin binding. Trichloroacetic acid affects bilirubin-albumin binding but to a degree that would be dangerous only in infants with an unusual accumulation of this metabolite.
水合氯醛用作需要通气支持的婴儿的镇静剂。其代谢产物三氯乙醇和三氯乙酸在血清中蓄积并与蛋白质结合。使用过氧化物酶法和透析速率法测试了这些化学物质可能与胆红素竞争白蛋白结合的可能性。水合氯醛和三氯乙醇对胆红素-白蛋白结合没有影响。三氯乙酸会影响胆红素-白蛋白结合，但仅在这种代谢产物异常蓄积的婴儿中才会达到危险程度。
