Hobara T, Kobayashi H, Kawamoto T, Iwamoto S, Sakai T
Pharmacol Toxicol. 1987 Jul;61(1):58-62. doi: 10.1111/j.1600-0773.1987.tb01773.x.
To examine the details concerning that part of TRI metabolism which was carried out by the extrahepatic organs, we studied the extrahepatic metabolism of chloral hydrate (CH), free-trichloroethanol (F-TCE) and trichloroacetic acid (TCA) using a method developed in our laboratory. Bypass and non-bypass dogs were given CH, F-TCE and TCA, and we compared the concentrations these substances and their metabolites in the serum and urine of the two groups of animals. In the bypass dogs, F-TCE, TCA and conjugated-trichloroethanol (Conj-TCE) appeared in the blood and urine 30 min. after the CH administration, and TCA and Conj-TCE appeared 30 min. after the F-TCE. All levels of administered substance were higher in bypass dogs than in non-bypass dogs, and the compounds were metabolized in small amounts in the extrahepatic organs compared with the liver. Therefore, administered substances remained at high levels in the serum and were excreted in large amounts in the urine in the form of unchanged substances. The metabolized percentage volumes of CH to TCA in the bypass dogs were 10-20%, and those of F-TCE to TCA were very small, while these percentage values of CH to F-TCE were the same or slightly smaller, respectively. Moreover, trichloroethylene (TRI) acts to decrease the leukocyte count in the blood, but the TRI metabolites described above do not have this function.
为了研究三氯乙烯（TRI）代谢中由肝外器官进行的那部分代谢的详细情况，我们使用本实验室开发的方法研究了水合氯醛（CH）、游离三氯乙醇（F-TCE）和三氯乙酸（TCA）的肝外代谢。对旁路和非旁路犬给予CH、F-TCE和TCA，并比较两组动物血清和尿液中这些物质及其代谢物的浓度。在旁路犬中，给予CH后30分钟，血液和尿液中出现F-TCE、TCA和结合三氯乙醇（Conj-TCE），给予F-TCE后30分钟出现TCA和Conj-TCE。旁路犬中所有给予物质的水平均高于非旁路犬，与肝脏相比，这些化合物在肝外器官中的代谢量较少。因此，给予的物质在血清中保持高水平，并以未变化物质的形式大量排泄到尿液中。旁路犬中CH转化为TCA的代谢百分比为10-20%，F-TCE转化为TCA的代谢百分比非常小，而CH转化为F-TCE的这些百分比值分别相同或略小。此外，三氯乙烯（TRI）可降低血液中的白细胞计数，但上述TRI代谢物不具有此功能。
