Tjørnehøj K, Eriksen L, Aalbaek B, Nansen P
Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
Parasitol Res. 1992;78(6):525-8. doi: 10.1007/BF00931575.
In an experiment including 8 groups of 15 mice, the effect of migrating Ascaris suum larvae in the lungs on the establishment and pathogenicity of aerosol exposure to Pasteurella multocida was investigated. Following aerosol exposure to P. multocida, mice with migrating A. suum in their lungs developed more severe pneumonia and septicaemia than did parasite-free mice. The parasite-induced effect on bacterial pathogenicity was more marked for a non-toxin-producing P. multocida as compared with a toxin-producing strain of P. multocida, possibly due to the higher spontaneous pathogenicity of the non-toxigenic strain of P. multocida. The present results should encourage controlled experiments on possible interactions between A. suum and various airborne microbial infections in pigs.
在一项包含8组、每组15只小鼠的实验中,研究了猪蛔虫幼虫在肺部移行对通过气溶胶暴露感染多杀巴斯德菌的定植及致病性的影响。在通过气溶胶暴露感染多杀巴斯德菌后,肺部有猪蛔虫移行的小鼠比无寄生虫的小鼠发生了更严重的肺炎和败血症。与产毒素的多杀巴斯德菌菌株相比,寄生虫对非产毒素多杀巴斯德菌致病性的影响更为显著,这可能是由于非产毒素多杀巴斯德菌菌株的自发致病性更高。目前的结果应促使人们对猪蛔虫与猪的各种空气传播微生物感染之间可能的相互作用进行对照实验。