Curtis S E, Tisch D A, Todd K S, Simon J
Animal Sciences Department, College of Agriculture, University of Illinois, Urbana 61801.
Can J Vet Res. 1987 Oct;51(4):525-7.
Pulmonary deposition and clearance of bacteria were measured in weanling pigs, half of which had been inoculated at age 31 days with larvated Ascaris suum ova. Seven days later, when breathing signs of larval migration were pronounced, all pigs were exposed to aerosolized Escherichia coli (strain B). Then, either immediately after aerosol exposure (for deposition assessment) or immediately after a 120 minute period in filtered air (for clearance), bacteria in the pigs' lungs were counted. Ascarid ova-inoculated pigs did not differ significantly from control pigs for number of bacteria in the lungs after aerosol exposure, but after the 120 minute clearance period they had 7.2 times more than did the control pigs. Thus, in weanling pigs, the breathing-pattern changes that were evident during ascarid-larval migration did not affect pulmonary deposition of inhaled bacteria significantly, but the presence of ascarid larvae in the lungs was associated with impaired pulmonary bacterial clearance.
在断奶仔猪中测量了细菌的肺沉积和清除情况，其中一半仔猪在31日龄时接种了含幼虫的猪蛔虫卵。七天后，当幼虫移行的呼吸体征明显时，所有仔猪都暴露于雾化的大肠杆菌（B菌株）中。然后，在气溶胶暴露后立即（用于沉积评估）或在过滤空气中放置120分钟后立即（用于清除评估），对仔猪肺中的细菌进行计数。接种蛔虫卵的仔猪在气溶胶暴露后肺中细菌数量与对照仔猪无显著差异，但在120分钟的清除期后，其肺中细菌数量是对照仔猪的7.2倍。因此，在断奶仔猪中，蛔虫幼虫移行期间明显的呼吸模式变化并未显著影响吸入细菌的肺沉积，但肺中存在蛔虫幼虫与肺细菌清除受损有关。
