Sarnyai Z, Szabó G, Kovács G L, Telegdy G
Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Pharmacol Biochem Behav. 1992 Oct;43(2):491-4. doi: 10.1016/0091-3057(92)90182-f.
Subchronic administration of cocaine induces behavioral sensitization (increasing hypermotility) to a challenge dose of the drug administered 72 h after the cessation of treatment. The effects of repeated administration of the neurohypophyseal hormones oxytocin (OXT) and arginine8-vasopressin (AVP) on the development of behavioral sensitization induced by subchronic treatment with cocaine were investigated in mice. Repeated treatment of OXT and AVP did not modify the locomotor stimulatory effect of the challenge dose of cocaine in cocaine-naive control animals. OXT in a dose of 0.5 microgram (sc) augmented the cocaine-induced behavioral sensitization. In contrast, AVP (0.005-0.5 microgram/mouse, sc) dose dependently attenuated the development of sensitization to the hypermotility-inducing effect of cocaine. The results suggest that the behavioral sensitization induced by cocaine can be modulated in opposite directions by neurohypophyseal hormones.
可卡因的亚慢性给药会诱导行为敏化（增加运动亢进），对在停止治疗72小时后给予的一剂激发剂量药物产生反应。在小鼠中研究了神经垂体激素催产素（OXT）和精氨酸加压素（AVP）重复给药对可卡因亚慢性治疗诱导的行为敏化发展的影响。在未接触过可卡因的对照动物中，OXT和AVP的重复治疗并未改变激发剂量可卡因的运动刺激作用。剂量为0.5微克（皮下注射）的OXT增强了可卡因诱导的行为敏化。相反，AVP（0.005 - 0.5微克/小鼠，皮下注射）剂量依赖性地减弱了对可卡因诱导的运动亢进作用的敏化发展。结果表明，可卡因诱导的行为敏化可被神经垂体激素以相反方向调节。
