Sarnyai Z, Babarczy E, Kriván M, Szabó G, Kovács G L, Barth T, Telegdy G
Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Neuropeptides. 1991 May;19(1):51-6. doi: 10.1016/0143-4179(91)90073-r.
The effects of oxytocin (OXT), arginine- and lysine-vasopressin (AVP and LVP) and an OXT-receptor antagonist on cocaine-induced sniffing behaviour were investigated in rats. OXT, but not AVP or LVP injected subcutaneously (s.c.) attenuated cocaine-induced sniffing. The effect of OXT (s.c.) was inhibited by an OXT-receptor antagonist administered intracerebroventricularly (i.c.v.). I.c.v. administration of different doses of OXT in nanogram quantities caused a dose-dependent attenuation of cocaine-induced sniffing. Local cerebral microinjection of OXT into the accumbens nucleus and olfactory tubercle but not into the olfactory nucleus, central amygdaloid nucleus or caudate nucleus, inhibited the cocaine-induced sniffing behaviour. These results demonstrate that OXT selectively attenuates the cocaine-induced stereotyped behaviour through basal forebrain target sites.
在大鼠中研究了催产素（OXT）、精氨酸血管加压素和赖氨酸血管加压素（AVP和LVP）以及一种OXT受体拮抗剂对可卡因诱导的嗅探行为的影响。皮下注射（s.c.）OXT可减弱可卡因诱导的嗅探，但AVP或LVP则无此作用。脑室内注射（i.c.v.）一种OXT受体拮抗剂可抑制皮下注射（s.c.）OXT的作用。脑室内注射纳克量的不同剂量OXT可导致可卡因诱导的嗅探呈剂量依赖性减弱。向伏隔核和嗅结节局部脑内微量注射OXT，但不向嗅核、中央杏仁核或尾状核注射，可抑制可卡因诱导的嗅探行为。这些结果表明，OXT通过基底前脑靶位点选择性地减弱可卡因诱导的刻板行为。
