Sarnyai Z, Vecsernyés M, Laczi F, Bíró E, Szabó G, Kovács G L
Alcohol and Drug Abuse Research Center, McLean Hospital, Belmont, Massachusetts 02178-9106.
Neuropeptides. 1992 Sep;23(1):27-31. doi: 10.1016/0143-4179(92)90006-i.
The effects of acute and chronic cocaine treatments on the levels of the neurohypophyseal hormones oxytocin (OXT) and vasopressin (AVP) in the plasma and in different brain structures in rats were measured by radioimmunoassay (RIA). Acute cocaine treatment had no effect on the level of OXT in the plasma or in the amygdala, but increased OXT contents were measured in the hypothalamus and in the hippocampus. The OXT levels in the basal forebrain structures (including the septum and the nucleus accumbens) were decreased by a single dose of cocaine. The acute injection of cocaine increased the level of AVP in the plasma, and decreased contents of OXT were measured in the amygdala and in the basal forebrain. Repeated treatment with cocaine decreased the level of OXT in the plasma, hypothalamus and hippocampus. The AVP contents were decreased in all of the brain structures investigated, but no change was caused in the plasma level of AVP by repeated injections of cocaine. These results demonstrate complex, region-specific interactions between cocaine and the neurohypophyseal hormones in the brain and in the periphery underlying the alteration in behavioral and autonomic functions caused by acute and chronic cocaine exposure.
通过放射免疫分析法（RIA）测定了急性和慢性可卡因处理对大鼠血浆及不同脑区中神经垂体激素催产素（OXT）和血管加压素（AVP）水平的影响。急性可卡因处理对血浆或杏仁核中OXT水平无影响，但在下丘脑和海马体中检测到OXT含量增加。单次注射可卡因会降低基底前脑结构（包括隔区和伏隔核）中的OXT水平。急性注射可卡因会使血浆中AVP水平升高，且在杏仁核和基底前脑中检测到OXT含量降低。重复给予可卡因会降低血浆、下丘脑和海马体中的OXT水平。在所研究的所有脑区中AVP含量均降低，但重复注射可卡因对血浆中AVP水平无影响。这些结果表明，在急性和慢性可卡因暴露引起的行为和自主功能改变的基础上，大脑和外周中可卡因与神经垂体激素之间存在复杂的、区域特异性的相互作用。
