Akojie F O, Fung L W
Department of Chemistry, Loyola University of Chicago, Illinois 60626.
Planta Med. 1992 Aug;58(4):317-20. doi: 10.1055/s-2006-961475.
The amounts of phenylalanine and hydroxybenzoic acid in a Cajanus cajan methanolic extract were estimated. Results showed that the amount of phenylalanine and hydroxybenzoic acid per gram weight of bean was 4.92 mg +/- 0.13 mg and 21.0 mg +/- 3.0 micrograms, respectively. Sickling inhibition was observed to be efficient with the extract which contains a mixture of phenylalanine (0.69 mg/ml) and p-hydroxybenzoic acid (10.5 micrograms/ml), equivalent to those found in bean extract. The additive antisickling effect of both compounds can be therapeutically exploited for the treatment of sickle cell anemia.
对木豆甲醇提取物中的苯丙氨酸和羟基苯甲酸含量进行了测定。结果表明，每克豆类中苯丙氨酸和羟基苯甲酸的含量分别为4.92毫克±0.13毫克和21.0毫克±3.0微克。观察到含有苯丙氨酸（0.69毫克/毫升）和对羟基苯甲酸（10.5微克/毫升）混合物的提取物具有有效的镰变抑制作用，其含量与豆类提取物中的含量相当。这两种化合物的相加抗镰变作用可用于镰状细胞贫血治疗的临床应用。
