Suzuki F, Nakao N, Nikaido O, Kondo S
Division of Radiation Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
Radiat Res. 1992 Sep;131(3):290-6.
The Mongolian gerbil (Meriones unguiculatus) is known to be one of the most radioresistant animals. We have examined the X-ray sensitivity of normal diploid fibroblasts from Mongolian gerbil embryos compared with those of cultured embryo cells obtained from various laboratory animals and a normal human. There was a wide difference in X-ray sensitivity for cell killing among different mammalian species. The D0 values for Mongolian gerbil cells ranged from 2.08 to 2.28 Gy, values which are twice as high as those for human cells. The mean D0 value for human cells was 1.06 Gy. Mouse, rat, Chinese hamster, and Syrian/golden hamster cells showed similar D0 values ranging from 1.30 to 1.56 Gy. When cells were irradiated with X rays, ten times more chromosome aberrations were detected in human cells than in Mongolian gerbil cells. The frequencies of chromosome aberrations in other rodent cells were between the values for cells from humans and those from gerbils. These data indicate that the Mongolian gerbil cells are resistant to X-ray-induced cell killing and chromosome aberrations, and that the radiation sensitivity of mammalian cells in primary culture may be reflected by their radioresistance in vivo.
蒙古沙鼠（长爪沙鼠）是已知最具辐射抗性的动物之一。我们已检测了来自蒙古沙鼠胚胎的正常二倍体成纤维细胞的X射线敏感性，并与从各种实验动物和正常人类获得的培养胚胎细胞进行了比较。不同哺乳动物物种之间在细胞杀伤的X射线敏感性方面存在很大差异。蒙古沙鼠细胞的D0值范围为2.08至2.28 Gy，这些值是人类细胞的两倍。人类细胞的平均D0值为1.06 Gy。小鼠、大鼠、中国仓鼠和叙利亚/金黄仓鼠细胞显示出相似的D0值，范围为1.30至1.56 Gy。当用X射线照射细胞时，在人类细胞中检测到的染色体畸变比在蒙古沙鼠细胞中多十倍。其他啮齿动物细胞中的染色体畸变频率介于人类细胞和沙鼠细胞的值之间。这些数据表明，蒙古沙鼠细胞对X射线诱导的细胞杀伤和染色体畸变具有抗性，并且原代培养的哺乳动物细胞的辐射敏感性可能由其体内的辐射抗性反映出来。
