Ikeda T, Ninomiya K, Sugi K, Enjoji Y, Abe R, Yamaguchi T, Yabuki S, Machii K, Takahashi K, Naoe S
Third Department of Internal Medicine, Toho University School of Medicine Ohashi Hospital.
Kokyu To Junkan. 1992 Oct;40(10):975-80.
The purpose of this study was to examine the appropriate frequency of radiofrequency catheter ablation (RFA) for ventricular tachycardia. Radiofrequency energy generated by a device in which the frequency could be changed, was delivered from an electrode catheter with an electrode tip-width of 4 mm. RFA was performed for 10 seconds with 20W (50V x 0.4A) using 7 different frequencies from 10 to 500 kHz on ventricular myocardium in vitro and in anesthetized dogs. The ablated lesion was significantly larger with RFA of 200-300 kHz in both surface area and depth (p less than 0.05). The appearance of ventricular arrhythmia during RFA increased as the frequency decreased, and one dog applied with RFA of 100 kHz had spontaneous ventricular fibrillation resulting in death. All dogs with frequency less than 100 kHz had a muscle cramp during RFA. We conclude that appropriate frequency seems to be 200-300 kHz to obtain a large ablated lesion, and a frequency higher than 300 kHz seems suitable to avoid arrhythmia. We also conclude that a frequency under 100 kHz should not be used.
本研究的目的是探讨用于室性心动过速的射频导管消融（RFA）的合适频率。由频率可改变的设备产生的射频能量，通过电极尖端宽度为4mm的电极导管传递。在体外和麻醉犬的心室心肌上，使用7种从10至500kHz的不同频率，以20W（50V×0.4A）进行10秒的RFA。在表面积和深度方面，200 - 300kHz的RFA产生的消融灶明显更大（p小于0.05）。RFA期间室性心律失常的发生率随频率降低而增加，一只接受100kHz RFA的犬发生自发性心室颤动并导致死亡。所有频率低于100kHz的犬在RFA期间均出现肌肉痉挛。我们得出结论，为获得大的消融灶，合适的频率似乎为200 - 300kHz，高于300kHz的频率似乎适合避免心律失常。我们还得出结论，不应使用低于100kHz的频率。
