1型糖尿病易感性的遗传分析。 - Suppr

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超能文献

Genetic analysis of susceptibility to type 1 diabetes.

作者信息

Todd J A

机构信息

Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, UK.

出版信息

Springer Semin Immunopathol. 1992;14(1):33-58. doi: 10.1007/BF00197131.

DOI:10.1007/BF00197131

PMID:1440197

Abstract

摘要

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Genetic analysis of susceptibility to type 1 diabetes.1型糖尿病易感性的遗传分析。

Springer Semin Immunopathol. 1992;14(1):33-58. doi: 10.1007/BF00197131.

HLA class II alleles and haplotypes in Icelandic Type I diabetic patients: comparison of Icelandic and Norwegian populations.冰岛1型糖尿病患者的HLA II类等位基因和单倍型：冰岛和挪威人群的比较。

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Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM.I类人类白细胞抗原与胰岛素依赖型糖尿病的发病年龄相关，而II类人类白细胞抗原则赋予对胰岛素依赖型糖尿病的易感性。

Diabetologia. 1995 Dec;38(12):1493-5. doi: 10.1007/BF00400620.

Definition of IDDM-associated HLA DQ and DX RFLPs by segregation analysis of multiplex sibships.通过对多个同胞家系的分离分析确定胰岛素依赖型糖尿病相关的HLA DQ和DX限制性片段长度多态性

Hum Immunol. 1989 Jan;24(1):51-63. doi: 10.1016/0198-8859(89)90046-3.

Lack of association of DMB polymorphism with insulin-dependent diabetes.DMB基因多态性与胰岛素依赖型糖尿病无关联。

J Autoimmun. 1997 Aug;10(4):395-400. doi: 10.1006/jaut.1997.0144.

HLA class II RFLPs are haplotype-specific.

Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:83-9. doi: 10.1101/sqb.1986.051.01.011.

HLA-D region RFLP and type 1 diabetes.HLA - D区域限制性片段长度多态性与1型糖尿病

Diabet Med. 1988 Sep;5(6):596-7. doi: 10.1111/j.1464-5491.1988.tb01060.x.

The immunogenetics of insulin-dependent diabetes.胰岛素依赖型糖尿病的免疫遗传学

Eye (Lond). 1993;7 ( Pt 2):209-13. doi: 10.1038/eye.1993.50.

Molecular aspects of HLA class II and some autoimmune diseases.人类白细胞抗原（HLA）II类分子与某些自身免疫性疾病的分子机制

Eur J Immunogenet. 1993 Jun;20(3):153-64. doi: 10.1111/j.1744-313x.1993.tb00106.x.

Structural and functional constraints on HLA class II dimers implicated in susceptibility to insulin dependent diabetes mellitus.与胰岛素依赖型糖尿病易感性相关的HLA II类二聚体的结构和功能限制

Baillieres Clin Endocrinol Metab. 1991 Sep;5(3):375-93. doi: 10.1016/s0950-351x(05)80137-5.

引用本文的文献

From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.从标志物到分子机制：全基因组关联研究时代后的1型糖尿病

Rev Diabet Stud. 2012 Winter;9(4):201-23. doi: 10.1900/RDS.2012.9.201. Epub 2012 Dec 28.

Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.通过在非肥胖糖尿病（NOD）小鼠中进行转基因表达，HLA - A2.1 Ⅰ类主要组织相容性复合体（MHC）分子介导致糖尿病性 T 细胞反应的功能证据。

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13753-8. doi: 10.1073/pnas.212221199. Epub 2002 Oct 2.

Immune mechanisms that regulate susceptibility to autoimmune type I diabetes.调节自身免疫性I型糖尿病易感性的免疫机制。

Clin Rev Allergy Immunol. 2000 Dec;19(3):247-64. doi: 10.1385/CRIAI:19:3:247.

I-E+ nonobese diabetic mice develop insulitis and diabetes.I-E+非肥胖糖尿病小鼠会发生胰岛炎和糖尿病。

J Exp Med. 1993 Sep 1;178(3):793-803. doi: 10.1084/jem.178.3.793.

HLA-DR-restricted T cell lines from newly diagnosed type 1 diabetic patients specific for insulinoma and normal islet beta cell proteins: lack of reactivity to glutamic acid decarboxylase.来自新诊断的1型糖尿病患者的HLA - DR限制性T细胞系，对胰岛素瘤和正常胰岛β细胞蛋白具有特异性：对谷氨酸脱羧酶无反应性。

Clin Exp Immunol. 1995 Oct;102(1):152-8. doi: 10.1111/j.1365-2249.1995.tb06649.x.

本文引用的文献

Physical map of the human HLA region.

Immunol Today. 1988;9(2):34-5. doi: 10.1016/0167-5699(88)91250-9.

Measuring the genetic contribution of a single locus to a multilocus disease.测量单个基因座对多基因座疾病的遗传贡献。

Clin Genet. 1984 Dec;26(6):529-42. doi: 10.1111/j.1399-0004.1984.tb01100.x.

A family study of the association between insulin dependent diabetes mellitus, autoantibodies and the HLA system.一项关于胰岛素依赖型糖尿病、自身抗体与HLA系统之间关联的家族研究。

Tissue Antigens. 1984 Oct;24(4):234-46. doi: 10.1111/j.1399-0039.1984.tb02132.x.

A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus.人类胰岛素基因附近的一个多态性位点与胰岛素依赖型糖尿病相关。

Diabetes. 1984 Feb;33(2):176-83. doi: 10.2337/diab.33.2.176.

Six HLA-D region alpha-chain genes on human chromosome 6: polymorphisms and associations of DC alpha-related sequences with DR types.人类6号染色体上的六个HLA - D区域α链基因：DCα相关序列的多态性及其与DR型的关联。

Proc Natl Acad Sci U S A. 1984 Jun;81(11):3461-5. doi: 10.1073/pnas.81.11.3461.

HLA-D region beta-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals.HLA-D区域β链DNA内切酶片段在HLA-DR相同的健康个体和胰岛素依赖型糖尿病个体之间存在差异。

Nature. 1983 Jun 30;303(5920):815-7. doi: 10.1038/303815a0.

Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses.BB大鼠患糖尿病所需的两个基因。来自周期性互交和回交的证据。

J Exp Med. 1984 Jun 1;159(6):1629-36. doi: 10.1084/jem.159.6.1629.

Pancreatic islet-cell damage in children with fatal viral infections.致命性病毒感染患儿的胰岛细胞损伤

Lancet. 1980 Aug 16;2(8190):354-8.

Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus.糖尿病患者的组织相容性（HL-A）抗原、淋巴细胞毒性抗体和组织抗体。

Diabetes. 1973 Jun;22(6):429-32. doi: 10.2337/diab.22.6.429.

HL-A antigens and diabetes mellitus.组织相容性白细胞抗原与糖尿病

Lancet. 1974 Oct 12;2(7885):864-6. doi: 10.1016/s0140-6736(74)91201-x.

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