多发性硬化症及其动物模型：主要组织相容性复合体和T细胞受体库的作用。 - Suppr

Suppr

超能文献

Multiple sclerosis and its animal models: the role of the major histocompatibility complex and the T cell receptor repertoire.

作者信息

Steinman L

机构信息

Department of Neurology, Stanford University, CA 94305-5235.

出版信息

Springer Semin Immunopathol. 1992;14(1):79-93. doi: 10.1007/BF00197133.

DOI:10.1007/BF00197133

PMID:1440199

Abstract

摘要

相似文献

Multiple sclerosis and its animal models: the role of the major histocompatibility complex and the T cell receptor repertoire.多发性硬化症及其动物模型：主要组织相容性复合体和T细胞受体库的作用。

Springer Semin Immunopathol. 1992;14(1):79-93. doi: 10.1007/BF00197133.

Coexpression of class I major histocompatibility antigen and viral RNA in central nervous system of mice infected with Theiler's virus: a model for multiple sclerosis.I类主要组织相容性抗原与病毒RNA在感染泰勒氏病毒的小鼠中枢神经系统中的共表达：一种多发性硬化症模型

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The antibody response in Theiler's virus infection: new perspectives on multiple sclerosis.

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Immune regulation by tolerization in EAE and in Theiler's murine encephalomyelitis virus (TMEV) infection (1).实验性自身免疫性脑脊髓炎（EAE）和泰勒氏鼠脑脊髓炎病毒（TMEV）感染中通过耐受实现的免疫调节(1)。

Acta Neurol (Napoli). 1991 Apr;13(2):107-112.

The Theiler's murine encephalomyelitis virus (TMEV) model for multiple sclerosis shows a strong influence of the murine equivalents of HLA-A, B, and C.用于多发性硬化症研究的泰勒氏鼠脑脊髓炎病毒（TMEV）模型显示，鼠类中与人类HLA - A、B和C相对应的基因具有强大影响。

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Genetic factors in demyelinating diseases: genes that control demyelination due to experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalitis virus.脱髓鞘疾病中的遗传因素：控制实验性变应性脑脊髓炎（EAE）和泰勒氏鼠脑脊髓炎病毒所致脱髓鞘的基因。

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Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus.泰勒氏鼠脑脊髓炎：一种脱髓鞘及病毒持续存在的模型。

Crit Rev Immunol. 1987;7(4):325-65.

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice.Ⅱ类分子限制性T细胞应答在泰勒氏鼠脑脊髓炎病毒诱导的脱髓鞘疾病中的作用。IV. 易感SJL/J小鼠中病毒衣壳蛋白VP2 N端免疫显性T细胞决定簇的鉴定

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Indictment of the microglia as the villain in multiple sclerosis.将小胶质细胞指认为多发性硬化症的罪魁祸首。

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Role of T cell receptor V beta genes in Theiler's virus-induced demyelination of mice.T细胞受体Vβ基因在泰勒氏病毒诱导的小鼠脱髓鞘中的作用。

J Immunol. 1992 Feb 1;148(3):921-7.

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Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.在HLA - DR4（B1*0401）受试者中，低亲和力的主要组织相容性复合体结合髓鞘碱性蛋白表位（第111 - 129位氨基酸残基）的免疫显性与受限的T细胞受体库相关。

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A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.一种来自主要组织相容性复合体II类β链第三高变区的合成肽作为治疗实验性自身免疫性脑脊髓炎的疫苗。

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Dominant V beta 8 gene usage in response to TNP: failure to use other V beta chains following removal of V beta 8+ T cells by monoclonal antibody in vivo.对三硝基苯（TNP）反应中优势性Vβ8基因的使用：体内用单克隆抗体去除Vβ8 + T细胞后未能使用其他Vβ链

Immunology. 1994 May;82(1):99-105.

Thymic epithelial defects and predisposition to autoimmune disease in BB rats.BB大鼠的胸腺上皮缺陷与自身免疫性疾病易感性

Am J Pathol. 1994 Dec;145(6):1517-25.

The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4.在存在和不存在人CD4的情况下，HLA - DR转基因小鼠对人髓鞘碱性蛋白和其他抗原的T细胞反应。

J Exp Med. 1995 Mar 1;181(3):867-75. doi: 10.1084/jem.181.3.867.

No linkage or association between multiple sclerosis and the myelin basic protein gene in affected sibling pairs.在患病同胞对中，多发性硬化症与髓鞘碱性蛋白基因之间不存在连锁或关联。

J Neurol Neurosurg Psychiatry. 1994 Oct;57(10):1191-4. doi: 10.1136/jnnp.57.10.1191.

本文引用的文献

THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS.用佐剂注射异种和同源脑组织在恒河猴中快速产生急性播散性脑脊髓炎。

J Exp Med. 1947 Jan 1;85(1):117-30. doi: 10.1084/jem.85.1.117.

ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS.猴实验性引起的伴髓鞘破坏的脑脊髓炎。

J Exp Med. 1935 Apr 30;61(5):689-702. doi: 10.1084/jem.61.5.689.

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS.对在猴子身上诱发急性弥散性脑脊髓炎的尝试的观察。

J Exp Med. 1933 Jun 30;58(1):39-53. doi: 10.1084/jem.58.1.39.

Rapid Production of Acute Disseminated Encephalomyelitis in Rhesus Monkeys by Injection of Brain Tissue With Adjuvants.用佐剂注射脑组织在恒河猴中快速产生急性播散性脑脊髓炎。

Science. 1946 Oct 18;104(2703):362-3. doi: 10.1126/science.104.2703.362.

Alterations in the expression of Ia antigens in F1 hybrid mice.F1 杂交小鼠中 Ia 抗原表达的改变。

Immunogenetics. 1981 Dec;14(6):507-16. doi: 10.1007/BF00350122.

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.免疫反应基因产物抗体的体内效应：实验性变应性脑脊髓炎的预防

Proc Natl Acad Sci U S A. 1981 Nov;78(11):7111-4. doi: 10.1073/pnas.78.11.7111.

Differential expression of Ia glycoprotein complexes in F1 hybrid mice detected with alloreactive cloned T cell lines.用同种反应性克隆T细胞系检测F1杂交小鼠中Ia糖蛋白复合物的差异表达。

J Immunol. 1982 Dec;129(6):2616-20.

Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex.免疫反应基因功能与Ia抗原的表达相关。I. 某些Ae和Eα链的优先缔合导致Ae:Eα复合物表达的定量缺陷。

J Exp Med. 1982 Feb 1;155(2):490-507. doi: 10.1084/jem.155.2.490.

Regions of allelic hypervariability in the murine A alpha immune response gene.小鼠Aα免疫反应基因中的等位基因高变区。

Cell. 1983 Aug;34(1):169-77. doi: 10.1016/0092-8674(83)90147-2.

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.T细胞上抗原特异性、主要组织相容性复合体限制的受体。VI. 针对受体同种异型的抗体。

J Exp Med. 1984 Aug 1;160(2):452-71. doi: 10.1084/jem.160.2.452.

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