Benoist C O, Mathis D J, Kanter M R, Williams V E, McDevitt H O
Cell. 1983 Aug;34(1):169-77. doi: 10.1016/0092-8674(83)90147-2.
The murine Ia antigens, a group of cell surface glycoproteins, are involved in the control of the immune response. The structure of one of these class II major histocompatibility complex molecules, A alpha, was recently deduced from sequence analysis of a cDNA clone produced from k haplotype mice. We have now isolated and sequenced A alpha cDNA clones from five other mouse haplotypes: d, b, f, u, and q. Sequence comparison revealed a surprisingly high degree of allelic polymorphism. Interestingly, amino acid substitutions were clustered within the first external domain of this polypeptide chain, particularly at a few highly variable positions. Functional implications of A alpha polymorphism and possible mechanisms for its generation are discussed.
鼠类Ia抗原是一组细胞表面糖蛋白，参与免疫应答的调控。这些II类主要组织相容性复合体分子之一Aα的结构，最近通过对k单倍型小鼠产生的一个cDNA克隆进行序列分析推导得出。我们现已从其他五个小鼠单倍型（d、b、f、u和q）中分离并测序了Aα cDNA克隆。序列比较显示出惊人的高度等位基因多态性。有趣的是，氨基酸替换集中在该多肽链的第一个外部结构域内，特别是在几个高度可变的位置。本文讨论了Aα多态性的功能意义及其产生的可能机制。
