Metelitsa V I, Ostrovskaia T P
Ter Arkh. 1992;64(4):39-43.
Nitrendipine (bypress) manufactured by Bayer Company in the form of 10 and 20 mg tablets and administered in a dose of 20-40 mg/day turned out an effective antihypertensive remedy in 65% of patients with arterial hypertension largely running a mild course. The effect of nitrendipine administered in a single daily dose of 20 mg did not differ from that attained with the same dose given in two intakes. The raising of the daily dose of nitrendipine from 20 to 40 mg was associated with augmentation of the hypotensive effect in 43.8% of the patients in whom the treatment in a dose of 20 mg a day had turned out ineffective. Under the conditions of the cross-over method with the use of the reference drugs belonging to three groups of the basic antihypertensive agents (nifedipine, propranolol, hydrochlorothiazide), the hypotensive effect of nitrendipine did not differ from that produced by the drugs under comparison (according to the mean group indicators and individual assessment of the efficacy). The tolerance of nitrendipine administered in a dose of 10 mg twice a day or in a dose of 20 mg once or twice a day was satisfactory.
拜耳公司生产的尼群地平（硝苯甲乙吡啶）有10毫克和20毫克片剂两种剂型，每日剂量为20 - 40毫克，结果表明，对于大部分病情较轻的动脉高血压患者，该药物在65%的患者身上显示出有效的降压效果。每日单次服用20毫克尼群地平的效果与分两次服用相同剂量的效果并无差异。在每日服用20毫克治疗无效的患者中，将尼群地平的每日剂量从20毫克提高到40毫克，43.8%的患者降压效果增强。在交叉试验方法的条件下，使用属于三类基本降压药（硝苯地平、普萘洛尔、氢氯噻嗪）的对照药物，尼群地平的降压效果与对照药物相比并无差异（根据组平均指标和个体疗效评估）。每日两次服用10毫克或每日一次或两次服用20毫克尼群地平的耐受性良好。
