Rumiantsev I Sh, Kaznacheeva I G, Abdiadilova L V, Kozlov V V
Ter Arkh. 1992;64(6):35-9.
The content of medium-sized molecules (MSM) in the blood serum was measured in 52 patients with exacerbation of chronic glomerulonephritis (CGN) given pathogenetic therapy. All the patients manifested an initial rise of the content of MSM. Administration of cytostatics and (or) glucocorticoids led to the regression of the nephrotic syndrome in 32 patients. In 20 patients, it was ineffective. All the patients in whom the treatment appeared effective demonstrated the lowering of the content of MSM 2 weeks after the treatment initiation, which outstripped the dynamics of the other parameters characteristic of CGN exacerbation. At the same time the urinary clearance of MSM remained unchanged. The patients in whom the pathogenetic therapy turned out ineffective manifested an increase of the blood content of MSM and of the urinary clearance of these substances. It is suggested that the test with the detection of the urinary clearance and the content of MSM in the blood serum may be used before the treatment and 2 weeks after its initiation to early estimate the treatment efficacy. The prognostic value of the positive test is 82%, that of the negative 80%. It is assumed that the mechanism that triggers the increase of the rate of MSM generation may lie in lipid peroxidation activation.
对52例接受病因治疗的慢性肾小球肾炎（CGN）急性加重期患者测定了血清中分子物质（MSM）的含量。所有患者均表现出MSM含量最初升高。给予细胞抑制剂和（或）糖皮质激素后，32例患者的肾病综合征得到缓解。20例患者治疗无效。所有治疗有效的患者在开始治疗2周后MSM含量降低，其下降幅度超过CGN急性加重期的其他特征参数变化。同时，MSM的尿清除率保持不变。病因治疗无效的患者血清中MSM含量及这些物质的尿清除率增加。建议在治疗前及开始治疗2周后检测血清MSM含量及尿清除率，以早期评估治疗效果。该检测阳性的预后价值为82%，阴性为80%。推测引发MSM生成速率增加的机制可能在于脂质过氧化激活。
