[A clinico-morphological analysis of the efficacy of therapy in chronic glomerulonephritis using prednisone, a cytostatic, an anticoagulant and an antiaggregant].

Four-component therapy (chlorbutin 0.2 mg, prednisone [correction of prednisolone] 60 mg, curantyl 400 mg/day per os, i.v. heparin 10,000 U twice a day) was given for 9-36 months to 76 patients with chronic glomerulonephritis (CGN). A statistically significant lowering of proteinuria was achieved irrespective of CGN clinicomorphological variant. As indicated by remission frequency and normalization of urinary osmotic concentration, efficacy of the above treatment is related to a clinical CGN type. Because clinical and morphological CGN types are correlated, the disease morphology and treatment effect are associated. The treatment proved effective in nephrotic mesangioproliferative, mesangiocapillary glomerulonephritis, focal-segmental glomerular sclerosis, active nephritic mesangiocapillary glomerulonephritis and inactive nephritic mesangioproliferative and mesangiocapillary glomerulonephritis. Nephrotic-hypertonic focal-segmental glomerulosclerosis and mesangiocapillary glomerulonephritis were resistant to therapy.