Heath D A
Metab Bone Dis Relat Res. 1981;3(4-5):343-5. doi: 10.1016/0221-8747(81)90051-5.
18 patients with Paget's disease have received 27 courses of mithramycin therapy. This treatment has proved to be very effective in rapidly relieving bone pain due to Paget's disease--relief being apparent in 4 to 5 days. A dose of 10 micrograms/kg/day for 10 days is effective, well tolerated and to date free of serious side effects. Such treatment is particularly indicated in complicated cases with other possible explanations for the pain. Long term relief is unusual unless calcitonin or sodium etidronate is added.
18例佩吉特氏病患者接受了27个疗程的光辉霉素治疗。事实证明，这种治疗方法对于迅速缓解佩吉特氏病引起的骨痛非常有效——疼痛在4至5天内明显减轻。每日剂量为10微克/千克，持续10天，效果良好，耐受性佳，且迄今为止未出现严重副作用。对于伴有其他可能导致疼痛原因的复杂病例，这种治疗方法尤为适用。除非加用降钙素或依替膦酸钠，否则很难实现长期缓解。
