铜绿微囊藻205株中一种新微囊藻毒素的结构测定与毒性研究
Structure determination and toxicity of a new microcystin from Microcystis aeruginosa strain 205.
作者信息
Kiviranta J, Namikoshi M, Sivonen K, Evans W R, Carmichael W W, Rinehart K L
机构信息
Department of Pharmacy, University of Helsinki, Finland.
出版信息
Toxicon. 1992 Sep;30(9):1093-8. doi: 10.1016/0041-0101(92)90054-9.
A new hepatotoxic microcystin was isolated from the cyanobacterium Microcystis aeruginosa strain 205. Its structure was found to be [Dha7]microcystin-RR as determined by amino acid analysis, mass spectrometry and 1H NMR spectroscopy. LD50 value (i.p. mouse) of this toxin was 180 micrograms/kg. The 48 hr lethal concentration (48-hr-LC50) of the toxin for larvae of the yellow fever mosquito, Aedes aegypti, was 14.9 micrograms/ml.
从铜绿微囊藻205菌株中分离出一种新的具有肝毒性的微囊藻毒素。通过氨基酸分析、质谱和1H核磁共振光谱测定，其结构为[Dha7]微囊藻毒素-RR。该毒素的半数致死剂量（腹腔注射小鼠）为180微克/千克。该毒素对黄热病蚊子埃及伊蚊幼虫的48小时致死浓度（48小时-LC50）为14.9微克/毫升。
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