Sivonen K, Namikoshi M, Evans W R, Gromov B V, Carmichael W W, Rinehart K L
Department of Microbiology, University of Helsinki, Finland.
Toxicon. 1992 Nov;30(11):1481-5. doi: 10.1016/0041-0101(92)90524-9.
Five microcystins were obtained from Microcystis aeruginosa strain CALU 972 isolated from a hepatotoxic water bloom collected in Lake Kroshnosero (Russia). The structure of a new toxin (1) was determined as [Dha7]microcystin-YR by amino acid analyses and fast atom bombardment mass spectrometry, and the toxins 2, 3, 4, and 5 were assigned the structures as [Dha7]microcystin-LR, [D-Asp3,Dha7]microcystin-LR, [Dha7]microcystin-RR, and [D-Asp3,Dha7]microcystin-RR, respectively, by direct comparison with authentic samples.
从俄罗斯克罗斯诺塞罗湖采集的具有肝毒性的水华中分离出的铜绿微囊藻菌株CALU 972中获得了五种微囊藻毒素。通过氨基酸分析和快原子轰击质谱法确定了一种新毒素（1）的结构为[Dha7]微囊藻毒素-YR，通过与标准样品直接比较，将毒素2、3、4和5的结构分别确定为[Dha7]微囊藻毒素-LR、[D-Asp3,Dha7]微囊藻毒素-LR、[Dha7]微囊藻毒素-RR和[D-Asp3,Dha7]微囊藻毒素-RR。
