Liapina L A, Kondashevskaia M V, Kokriakov V N, Shamova O V
Vopr Med Khim. 1992 Jan-Feb;38(1):39-42.
Heparin was shown to form complexes with cation non-enzymatic protein defensin from neutrophils. The complex obtained in vitro did not affect the anticoagulation and fibrinolytic properties of blood, whereas defensin decreased the content of heparin, rates of non-enzymatic fibrinolysis and total fibrinolytic activity while heparin stimulated the anticoagulation activity of blood plasma. Interaction of heparin with defensin appears to be involved in protective mechanism responsible for neutralization of both the heparin anticoagulation activity and the defensin properties related to inhibition of nonenzymatic fibrinolysis.
研究表明，肝素可与中性粒细胞中的阳离子非酶蛋白防御素形成复合物。体外获得的该复合物不影响血液的抗凝和纤溶特性，而防御素会降低肝素含量、非酶纤溶速率和总纤溶活性，同时肝素会刺激血浆的抗凝活性。肝素与防御素的相互作用似乎参与了一种保护机制，该机制负责中和肝素的抗凝活性以及防御素与抑制非酶纤溶相关的特性。
