Kudriashov B A, Ashmarin I P, Liapina L A, Kondashevskaia M V, Kokriakov V N
Fiziol Zh SSSR Im I M Sechenova. 1988 Dec;74(12):1759-64.
I. v. administration of defensin, nonenzyme cationic protein consisting of some peptides, to the rats with either activation or depression of anticoagulating system produced a moderate decrease of anticoagulating and fibrinolytic properties of the blood and did not intensify the depression of anticoagulating system. Neither did defensin affect the response of anticoagulating system when administered prior to injection of tromboplastin. These properties of defensin make it an efficient hemostatic drug.
向抗凝系统激活或抑制的大鼠静脉注射防御素（一种由某些肽组成的非酶阳离子蛋白），可使血液的抗凝和纤溶特性适度降低，且不会加剧抗凝系统的抑制。在注射凝血活酶之前给予防御素时，它也不会影响抗凝系统的反应。防御素的这些特性使其成为一种有效的止血药物。
