Kolontsov A A, Ustin A V, Shubina N G, Piria A A, Makarov V V
Vopr Virusol. 1992 May-Jun;37(3):165-8.
African swine fever virus polypeptides p14 and p31 are synthesized in the presence of phosphonacetic acid which inhibits viral DNA replication, and therefore they are early viral proteins. These polypeptides were found to be localized on plasma membranes by immunofluorescence with monospecific antisera and monoclonal antibodies and by selective solubilization of infected cells. The p14-specific antibodies mediate complement-dependent cytolysis and antibody-dependent cytotoxicity of the cells infected with African swine fever virus.
非洲猪瘟病毒多肽p14和p31是在膦乙酸存在的情况下合成的，膦乙酸会抑制病毒DNA复制，因此它们是病毒早期蛋白。通过用单特异性抗血清和单克隆抗体进行免疫荧光检测以及对感染细胞进行选择性溶解，发现这些多肽定位于质膜上。p14特异性抗体介导感染非洲猪瘟病毒的细胞的补体依赖性细胞溶解和抗体依赖性细胞毒性。
