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[老年人的胃肠动力]

[Gastrointestinal motility in the elderly].

作者信息

Lux G, Bozkurt T, Orth K H

机构信息

I. Medizinische Klinik, Städtisches Krankenhaus, Solingen.

出版信息

Z Gerontol. 1992 Sep-Oct;25(5):295-303.

PMID:1441709
Abstract

The existence of specific, age-related changes in gastrointestinal motility with clinical significance is controversial. Beside the more infrequent primary motility disorders, secondary motility disturbances associated with collagen vascular diseases, endocrinopathies, and neuromuscular diseases are prominent in the older and often multimorbid patients. Especially in geriatric patients, motility associated symptoms are undesired side-effects of drug therapy. The pathophysiology, clinical syndromes, and therapeutic principles of motility disorders in the elderly are discussed. The major symptoms of esophageal dysfunction are dysphagia, chest pain, heartburn, and regurgitation. Oropharyngeal dysphagia, mostly caused by cerebrovascular accidents and other neurologic disorders, leads to disturbances in food intake, and is often complicated by broncho-pulmonary infections arising from recurrent aspiration of food or saliva. Gastrointestinal reflux disease and spastic motility disorders of the esophagus are regarded as possible causes of angina-like chest pain after exclusion of cardiac diseases. Motility disturbances of the stomach and small bowel are often related to systemic disease (i.e., diabetes mellitus, chronic intestinal pseudo-obstruction) of drug side-effects. Mental and physical decline, reduced fluid intake, and constipating drugs are the most relevant factors for idiopathic constipation in the elderly. Fecal incontinence means a great psychological strain for older patients and leads to social isolation.

摘要

胃肠道动力存在具有临床意义的特定年龄相关变化,这一点存在争议。除了较少见的原发性动力障碍外,与胶原血管疾病、内分泌病和神经肌肉疾病相关的继发性动力障碍在老年且往往患有多种疾病的患者中较为突出。尤其是在老年患者中,动力相关症状是药物治疗的不良副作用。本文讨论了老年人动力障碍的病理生理学、临床综合征及治疗原则。食管功能障碍的主要症状为吞咽困难、胸痛、烧心和反流。口咽吞咽困难主要由脑血管意外和其他神经系统疾病引起,导致食物摄入障碍,且常因食物或唾液反复误吸引发支气管肺部感染而复杂化。排除心脏疾病后,胃食管反流病和食管痉挛性动力障碍被视为心绞痛样胸痛的可能原因。胃和小肠的动力障碍常与全身性疾病(如糖尿病、慢性肠道假性梗阻)或药物副作用有关。精神和身体衰退、液体摄入量减少以及致便秘药物是老年人特发性便秘最相关的因素。大便失禁给老年患者带来巨大的心理压力,并导致社交孤立。

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