Habib G B, Zoghbi W A
Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
Am Heart J. 1992 Nov;124(5):1313-20. doi: 10.1016/0002-8703(92)90417-t.
To assess right ventricular filling dynamics in systemic hypertension, pulsed Doppler echocardiographic studies were obtained at the tricuspid and mitral anuli in 43 untreated hypertensive patients, aged 23 to 66 years, and in 42 age-matched normotensive control subjects. In hypertensive patients, the ratio of late to early peak filling velocity and atrial filling fraction were higher, while normalized peak filling rate, one third and one half filling fractions were lower, compared with control values. Right ventricular filling dynamics correlated poorly with age in hypertensive patients, and were unrelated to left ventricular mass or left ventricular wall thickness. Weak correlations were only found between right ventricular wall thickness and right ventricular peak late inflow velocity, first half and first third filling fractions. However, right ventricular filling dynamics were closely related to left ventricular filling dynamics in both hypertensive patients (r = 0.49 to 0.82) and normal individuals (r = 0.55 to 0.86). Thus right ventricular filling dynamics are altered in hypertension, independently of left ventricular mass or blood pressure, are weakly related to right ventricular thickness, but remain closely correlated to left ventricular filling dynamics.
为评估系统性高血压患者的右心室充盈动力学，对43例年龄在23至66岁之间未经治疗的高血压患者以及42例年龄匹配的血压正常对照者进行了三尖瓣和二尖瓣环处的脉冲多普勒超声心动图研究。与对照值相比，高血压患者的晚期与早期峰值充盈速度之比及心房充盈分数较高，而标准化峰值充盈率、三分之一和二分之一充盈分数较低。高血压患者的右心室充盈动力学与年龄的相关性较差，且与左心室质量或左心室壁厚度无关。仅在右心室壁厚度与右心室晚期峰值流入速度、前二分之一和前三分之一充盈分数之间发现微弱的相关性。然而，高血压患者（r = 0.49至0.82）和正常个体（r = 0.55至0.86）的右心室充盈动力学均与左心室充盈动力学密切相关。因此，高血压患者的右心室充盈动力学发生改变，独立于左心室质量或血压，与右心室厚度的相关性较弱，但仍与左心室充盈动力学密切相关。
