Zoghbi W A, Habib G B, Quinones M A
Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
Circulation. 1990 Oct;82(4):1316-24. doi: 10.1161/01.cir.82.4.1316.
To examine whether alterations in right ventricular filling dynamics occur with increasing age and to compare right and left ventricular filling in normal subjects, pulsed Doppler echocardiographic studies were performed at the tricuspid and mitral anuli in 50 normal volunteers (23 males and 27 females) with an age range of 5-66 years. An age-related decrease in peak early filling velocity, increase in peak late velocity, and augmentation in the late/early ratio of peak velocities at the tricuspid anulus were observed (r = -0.68, 0.63, and 0.84, respectively). Significant correlations were also found between age and first third, first half, and atrial filling fractions (r = -0.60, -0.72, and 0.69, respectively). Weaker relations were observed between heart rate and Doppler-derived diastolic parameters (r = 0.18-0.54). Right ventricular filling indexes related significantly to those of the left ventricle (r = 0.58-0.88), the best being for the late/early ratio of peak velocities. With inspiration, an increase in early and late right ventricular filling occurred, whereas a reduction in filling occurred in the left ventricle. Thus, careful consideration for age, heart rate, and respiration is necessary in examining the effect of disease states or therapeutics on the filling dynamics of either the right or left ventricle.
为了研究右心室充盈动力学改变是否随年龄增长而出现，并比较正常受试者的右心室和左心室充盈情况，对50名年龄在5至66岁的正常志愿者（23名男性和27名女性）进行了三尖瓣和二尖瓣环处的脉冲多普勒超声心动图研究。观察到三尖瓣环处早期充盈峰值速度随年龄增长而降低、晚期峰值速度增加以及晚期/早期峰值速度比值增大（r分别为-0.68、0.63和0.84）。年龄与前三分之一、前半部分以及心房充盈分数之间也存在显著相关性（r分别为-0.60、-0.72和0.69）。心率与多普勒衍生的舒张参数之间的关系较弱（r = 0.18 - 0.54）。右心室充盈指标与左心室充盈指标显著相关（r = 0.58 - 0.88），其中峰值速度的晚期/早期比值相关性最佳。吸气时，右心室早期和晚期充盈增加，而左心室充盈减少。因此，在检查疾病状态或治疗方法对右心室或左心室充盈动力学的影响时，有必要仔细考虑年龄、心率和呼吸因素。
