Wiesel M L, Mossard J M, Grunebaum L, Cazenave J P, Sacrez A
Service d'hémostase et de thrombose, INSERM U 311, centre régional de transfusion sanguine, Strasbourg, France.
Ann Biol Clin (Paris). 1992;50(1):15-9.
In order to determine a marker of prethrombotic states, reliable and easy to measure, we studied 200 patients under 60 years of age admitted to hospital for a precordial chest pain. Four groups were established: transmural myocardial infarction, acute infarction without Q wave, unstable angina and atypical chest pain. Fibrinogen, von Willebrand factor, cholesterol, and triglyceride levels were measured as well as the white cell and platelet counts. There was a statistically significant correlation between transmural myocardial infarction and increased levels of fibrinogen, von Willebrand factor and white blood cells. Von Willebrand factor was already increased in the acute phase of transmural infarction, reached a maximum on the fifth day and then decreased slowly during the following ten days. This study suggests that plasma von Willebrand factor could be a reliable marker of transmural myocardial infarction in the acute phase or during the two weeks following the thrombotic event.
为了确定一种可靠且易于测量的血栓前状态标志物，我们研究了200名因心前区胸痛入院的60岁以下患者。设立了四组：透壁性心肌梗死、无Q波急性梗死、不稳定型心绞痛和非典型胸痛。测量了纤维蛋白原、血管性血友病因子、胆固醇和甘油三酯水平以及白细胞和血小板计数。透壁性心肌梗死与纤维蛋白原、血管性血友病因子和白细胞水平升高之间存在统计学显著相关性。血管性血友病因子在透壁性梗死急性期就已升高，在第五天达到峰值，随后在接下来的十天内缓慢下降。这项研究表明，血浆血管性血友病因子可能是急性透壁性心肌梗死或血栓形成事件后两周内的可靠标志物。
