Margulis T, David M, Maor N, Soff G A, Grenadier E, Palant A, Aghai E
Thromb Haemost. 1986 Jun 30;55(3):366-8.
Recent studies have demonstrated elevations of von Willebrand Factor following acute myocardial infarction (AMI). In order to determine if this parameter may serve as a marker for AMI, we tested the blood levels of vWF and Factor VIII:C in 28 patients with AMI, 9 patients with unstable angina, 7 patients with atypical chest pain, and 25 healthy volunteers. The level of ristocetin cofactor activity of vWF was between 70 and 144% in the control group. In patients with AMI, the mean level of this activity was 175% on the first day following infarction, rose to a peak of 270% on the fifth and sixth days, and was still significantly greater than normal in all patients on the 14th day. The vWF:Ag level closely paralleled the rise of ristocetin cofactor activity of vWF, with a peak of 336% on day 5. FVIII:C was not significantly changed. No significant elevation of vWF was observed in patients with unstable angina. The ristocetin cofactor activity of vWF and vWF:Ag thus are sensitive biochemical indicators for recent AMI, and may serve as useful markers for up to 14 days following infarction, when the traditional enzymes have returned to normal levels.
近期研究表明，急性心肌梗死（AMI）后血管性血友病因子（vWF）水平会升高。为了确定该参数是否可作为AMI的标志物，我们检测了28例AMI患者、9例不稳定型心绞痛患者、7例非典型胸痛患者及25名健康志愿者的vWF和凝血因子VIII:C（FVIII:C）的血液水平。对照组中vWF的瑞斯托霉素辅因子活性水平在70%至144%之间。AMI患者在梗死第一天该活性的平均水平为175%，在第五天和第六天升至峰值270%，且在第14天时所有患者的该水平仍显著高于正常。vWF:Ag水平与vWF的瑞斯托霉素辅因子活性升高密切平行，在第5天达到峰值336%。FVIII:C无显著变化。不稳定型心绞痛患者未观察到vWF显著升高。因此，vWF的瑞斯托霉素辅因子活性和vWF:Ag是近期AMI的敏感生化指标，在传统酶已恢复至正常水平时，它们可作为梗死发生后长达14天的有用标志物。
