Coil D R, Giovanella B C, Greeff P J, Stehlin J S, Davis B R
St. Joseph Hospital Cancer Research Laboratory, Houston, Texas 77003.
Anticancer Res. 1992 Sep-Oct;12(5):1363-71.
Human melanomas serially passaged in nude mice as xenotransplants were used as models for the study of the effects of thermochemotherapy of human malignant tumours in vivo. Three such melanomas, one (BRO) fast-growing, one (SCH) slow-growing, and one (BEL) of intermediate growth rate, were chosen. One group was left untreated as a control, one received chemotherapy (cyclophosphamide), one received hyperthermia, and one a combination of both treatments. In all three tumours, the best results were obtained associating chemotherapy with hyperthermia. The fastest growing tumor responded more than the slower, which responded better than the slowest. This model should prove useful in testing the effectiveness of anticancer agents used in association with hyperthermia.
将人黑色素瘤作为异种移植物在裸鼠中连续传代，以此作为研究人体恶性肿瘤体内热化疗效果的模型。选取了三种这样的黑色素瘤，一种（BRO）生长迅速，一种（SCH）生长缓慢，另一种（BEL）生长速度中等。一组不进行治疗作为对照，一组接受化疗（环磷酰胺），一组接受热疗，还有一组接受两种治疗的联合。在所有三种肿瘤中，化疗与热疗联合取得了最佳效果。生长最快的肿瘤反应比生长较慢的更明显，生长较慢的又比生长最慢的反应更好。该模型在测试与热疗联合使用的抗癌药物的有效性方面应会被证明是有用的。
