Verschraegen C F, Mendoza J T, Kozielski A J, Giovanella B C
Stehlin Foundation for Cancer Research, Houston, Texas 77003, USA.
Anticancer Res. 1995 Jan-Feb;15(1):9-11.
Organ environment has been shown to modulate the efficacy of chemotherapy. A nude mouse model was used to study the influence of the in vivo environment on the sensitivity to chemotherapy of a human melanoma. A melanoma clone, SB1A, was implanted in two different sites (adrenals and subcutis) of nude mice which were subsequently treated with high-dose cyclophosphamide. After treatment, a 42% complete response rate was observed for the adrenal implants. No response was seen in the subcutis despite the same chemotherapy administration. This result is not attributable to differences in drug concentration in the target sites, because of the high-dose chemotherapy used. This model shows that the in vivo environment modifies the sensitivity to chemotherapy of a malignant melanoma clone. Further research is needed to clarify the role of host factors and of specific cell-stroma interactions that modify the biological behavior of malignant cells.
器官微环境已被证明可调节化疗疗效。使用裸鼠模型研究体内环境对人黑色素瘤化疗敏感性的影响。将黑色素瘤克隆株SB1A植入裸鼠的两个不同部位（肾上腺和皮下），随后用高剂量环磷酰胺进行治疗。治疗后，肾上腺植入物的完全缓解率为42%。尽管给予相同的化疗，但皮下植入物未见反应。由于使用了高剂量化疗，该结果并非归因于靶部位药物浓度的差异。该模型表明，体内环境会改变恶性黑色素瘤克隆株对化疗的敏感性。需要进一步研究以阐明宿主因素以及改变恶性细胞生物学行为的特定细胞-基质相互作用的作用。
